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Following the death of the Prophet in 632, the Muslim community failed to reach consensus on who should succeed him as the caliph. A majority of Muhammad's close followers supported the idea of an elected caliph, but a minority believed that leadership, or the imamate, should remain within the Prophet's family, passing first to Muhammad's cousin, son-in-law, and principal deputy, Ali ibn Abu Talib, and subsequently to Ali's sons and their male descendants. The majority, who believed they were following the sunna of the Prophet, became known as Sunni Muslims. To them, the caliph was the symbolic religious head of the community; however, caliphs would also rule as the secular leaders of a major empire for six centuries. The first four caliphs - Abu Bakr, Omar, Osman, and Ali - were chosen by a consensus of Muslim leaders. Subsequently, however, the caliphate was converted by its holders into a hereditary office, the first two dynasties being the Umayyad, which ruled from Damascus, and the second being the Abbasid, which ruled from Baghdad. After the Mongols captured Baghdad and executed the Abbasid caliph in 1258, a period of more than 250 years followed when no one was recognized as caliph by all Sunni Muslims. During the sixteenth century, the Ottoman Dynasty resurrected the title, and gradually even Muslims outside the Ottoman Empire came to accept the Ottoman sultan as the symbolic leader - caliph - of Sunni Islam.

The partisans of Ali - the Shiat Ali - evolved into a separate Islamic denomination that became known as the Shia. By the ninth century, however, the Shia Muslims split into numerous sects as a result of disagreements over which of several brothers was the legitimate leader, or imam, of the community. The major divisions occurred over the question of succession to the fourth, sixth, and twelfth imams. Consequently, the origins of almost all Shia sects can be traced to the followers of the fifth, seventh, or twelfth imam. By the fifteenth century, the sect known as the Twelve Imam Shia - a group that recognized Ali and eleven of his direct descendants as the legitimate successors to the Prophet - had emerged as the predominant Shia sect.

In addition to the orthodox Twelve Imam Shia, several sects that revered the twelve imams but otherwise subscribed to heterodox beliefs and practices emerged between the ninth and twelfth centuries. One of these heterodox sects, the Nusayri, originated in the mid-ninth century among the followers of the religious teacher Muhammad ibn Nusayr an Namiri. The Nusayri became established in what is now northern Syria and southern Turkey during the tenth century when a Shia dynasty based in Aleppo ruled the region. Because of the special devotion of the Nusayri to Ali, Sunni Muslims historically and pejoratively referred to them as Alevi (see The Alevi).

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